Dr. Lisa Johanna von Kleist

"Basic research wants to know the world, applied research wants to shape the world."
+49 (0) 30 310078 5824

Focus of work

  • Drug discovery
  • Biotechnology
  • Pharmaceutical industry
  • Cell Biology
  • Molecular Pharmacology
  • Technology transfer

Curriculum vitae

Dr. Lisa Johanna von Kleist studied chemistry at Gothenburg University in Sweden with a focus on molecular biology, biochemistry and pharmacology. She received her PhD from the Free University of Berlin in the field of biochemistry with a focus on the development of novel drugs against, among other things, viral uptake. Subsequently, she spent several years conducting studies, analyses and research in the fields of biotechnology and life sciences for public and private clients. In particular, she focused on drug discovery and technology transfer in the context of academic research and pharmaceutical companies as both employers and clients. Since 2019, she has been working at VDI/VDE Innovation + Technik GmbH as a research associate on behalf of the "Global Health" unit at the German Federal Ministry of Education and Research, among others.

Publications

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pervaiz, Sumaira; Kopp, Anja; von Kleist, Lisa; Stauber, Tobias (2019): Absolute Protein Amounts and Relative Abundance of Volume-regulated Anion Channel (VRAC) LRRC8 Subunits in Cells and Tissues Revealed by Quantitative Immunoblotting. In: International Journal of Molecular Sciences. Vol. 20, No. 23. S. 5879.
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von Kleist, Lisa; Aribunbat, Khandsuren; Braren, Ingke; Stauber, Tobias; Storch, Stephan; Danyukova, Tatyana (2019): A newly generated neuronal cell model of CLN7 disease reveals aberrant lysosome motility and impaired cell survival. In: Molecular Genetics and Metabolism. Vol. 126, NO. 2. S. 196-205.
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König, Benjamin ; von Kleist, Lisa; Stauber, Tobias (2017): Measurement of lysosomal ion homeostasis by fluorescence microscopy (Chapter 14). In: Seruca, Raquel et al. (Hrsg.). Fluorescence Imaging and Biological Quantification.
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Robertson, Mark J.; Horatscheck, André; Sauer, Samantha; von Kleist, Lisa; Baker, Jennifer R.; Stahlschmidt, Wiebke; Nazaré, Marc; Whiting, Ainslie; Chau, Ngoc; Robinson, Phillip J.; Haucke, Volker; McCluckey, Adam (2016): 5-Aryl-2-(naphtha-1-yl)sulfonamido-thiazol-4(5H)-ones as clathrin inhibitors†. In: Organic and Biomolecular Chemistry. Vol. 14, No. 47. S. 11266-11278.
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Luo, Lin; Xue, Jing; Kwan, Ann; Gamsjaeger, Roland; Wielens, Jerome; von Kleist, Lisa; Cubeddu, Liza; Guo, Zhong; Stow, Jennifer L.; Parker, Michael W.; Mackay, Joel P.; Robinson, Phillip J. (2016): The Binding of Syndapin SH3 Domain to Dynamin Proline-rich Domain Involves Short and Long Distance Elements. In: The Journal of Biological Cheminstry. Vol. 291, No. 18. S. 9411–9424.
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von Kleist, Lisa; Michaelis, Simon; Bartho, Kathrin; Graebner, Olivia; Schlief, Marén; Dreger, Mathias; Schrey, Anna K.; Sefkow, Michael; Kroll, Friedrich; Koester, Hubert; Luo, Yan (2016): Identification of Potential Off-target Toxicity Liabilities of Catechol-O-methyltransferase Inhibitors by Differential Competition Capture Compound Mass Spectrometry. In: Journal of Medicinal Chemistry. Vol. 59, No. 10. S. 4664–4675.
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Diezmann, F.; von Kleist, L.; Haucke, V.; Seitz, Oliver (2015): Probing heterobivalent binding to the endocytic AP-2 adaptor complex by DNA-based spatial screening. In: Organic & Biomolecular Chemistry. Vol. 13, No. 29. S. 8008-8015.
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Daniel, James A.; Chau, Ngoc; Abdel-Hamid, Mohammed K.; Hu, Lingbo; von Kleist, Lisa; Whiting, Ainslie; Krishnan, Sai; Maamary, Peter; Joseph, Shannon R.; Simpson, Fiona; Haucke, Volker; McCluskey, Adam; Robinson, Phillip J. (2015): Phenothiazine‐Derived Antipsychotic Drugs Inhibit Dynamin and Clathrin‐Mediated Endocytosis. In: Traffic. Vol. 16, No. S. S. 635-54.
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Robertson, Mark J.; Deane, Fiona M.; Stahlschmidt, Wiebke; Haucke, Volker; von Kleist, Lisa; Robinson, Phillip J.; McCluskey, Adam (2014): Synthesis of the Pitstop family of clathrin inhibitors. In: Journal of Medicinal Chemistry. Vol. 7, No. 1. S. 131–143.
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McGregor, Kylie A.; Robertson, Mark J.; Young, Kelly A.; von Kleist, Lisa; Stahlschmidt, Wiebke; Whiting, Ainslie; Chau, Ngoc; Robinson, Phillip J.; Haucke, Volker; McCluskey, Adam (2013): Development of 1,8-Naphthalimides as Clathrin Inhibitors. In: Journal of Medicinal Chemistry. Vol. 57, No. 1. S. 131-143.
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McCluskey, Adam; Daniel, James A.; Hadzic, Gordana; Chau, Ngoc; Clayton, Emma L.; Mariana, Anna; Whiting, Ainslie; Gorgani, Nick N.; Lloyd, Jonathan; Quan, Annie; Mochkanbaryans, Lia; Krishnan, Sai; Perera, Swetha; Chircop, Megan; von Kleist, Lisa; McGeachie, Andrew B.; Howes, Mark T.; Parton, Robert G.; Campbell, Michael; Sakoff, Jennette A.; Wang, Xuefeng; Sun, Jian-Yuan; Robertson, Mark J.; Deane, Fiona M.; Nguyen, Tam H.; Meunier, Frederic A.; Cousin, Michael A.; Robinson, Phillip J. (2013): Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis. In: Traffic (Copenhagen, Denmark). Vol. 14, No. 12. S. 1272–1289.
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Leclercq, Olivier; Bartho, Kathrin; Duelsner, Erik; von Kleist, Lisa; Gherardini, Pier Federico; Palmeri, Antonio; Helmer-Citterich, Manuela; Baumgart, Sabine; Späth, Gerald F. (2013): Enrichment of Leishmania donovani ATP-binding proteins using a staurosporine capture compound. In: Journal of Proteomics. Vol. 86. S. 97-104.
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Robertson, Mark J.; Hadzic, Gordana; Ambrus, Joseph; Pomè, D. Yuri; Hyde, Emily; Whiting, Ainslie; Mariana, Anna; von Kleist, Lisa; Chau, Ngoc; Haucke, Volker; Robinson, Phillip J.; McCluskey, Adam (2012): The Rhodadyns, a New Class of Small Molecule Inhibitors of Dynamin GTPase Activity. In: ACS Med Chem Lett. Vol. 3, No. 5. S. 352-356.
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von Kleist, Lisa; Stahschmidt, Wiebke; Bulut, Haydar; Gromova, Kira; Puchkov, Dmytro; Robertson, Mark J.; MacGregor, Kylie A.; Tomilin, Nikolay; Pechstein, Arndt; Chau, Ngoc; Chircop, Megan; Sakoff, Jennette; von Kries, Jens Peter; Saenger, Wolfram; Kräusslich, Hans-Georg; Shupliakov, Oleg; Robinson, Phillip J.; McCluskey, Adam; Haucke, Volker (2011): Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition. In: Cell. Vol. 146, No. 3. S. 471-484.
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von Kleist, Lisa; Haucke, Volker (2011): At the Crossroads of Chemistry and Cell Biology: Inhibiting Membrane Traffic by Small Molecules. In: Traffic,. Vol. 13, No. 4. S. 495-504.
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Khundadze, Mukhran; Ribaudo, Federico; Hussain, Adeela; Rosentreter, Jan; Nietzsche, Sandor; Thelen, Melanie; Winter, Dominic; Hoffmann, Birgit; Afzal, Muhammad Awais; Hermann, Tanja; de heus, Cecilia; Piskor, Eva-Maria; Kosan, Christian; Franzka, Patricia; von Kleist, Lisa; Stauber, Tobias; Klumperman, Judith; Damme, Markus; Proikas-Cezanne, Tassula; Hübner, Christian A. (1970): A mouse model for SPG48 reveals a block of autophagic flux upon disruption of adaptor protein complex five. In: Neurobiology of Disease. Vol. 127. S. 419-431.